TRI-EXPONENTIAL DISPOSITION PHARMACOKINETICS OF GENTAMICIN IN RABBITS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 26  (1) , 115-127
Abstract
Using a sensitive high-pressure liquid chromatographic method for the determination of gentamicin, plasma-level profiles of gentamicin were found to fit to a triexponential equation in 3 of 4 rabbits studied after bolus i.v. administration by the application of the Minimum Akaike''s Information Criterion Estimation (MAICE) method. This differs from the monoexponential or biexponential decay of gentamicin often reported in humans. Volumes of distribution of central compartment and at steady-state in rabbits were similar to those reported in humans. Extensive distribution and tissue binding of gentamicin in rabbits were indicated by their high Vdarea, about 3.9 l/kg. Rabbits may serve as a useful model for studying the mechanism and prediction of renal toxicity of gentamicin in patients.

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