A Novel Antiprotozoal Aminosteroid from Saracha punctata
- 19 September 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (11) , 1390-1393
- https://doi.org/10.1021/np9800654
Abstract
A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-d-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmaniabraziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.Keywords
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