Platelet‐Induced Autoagglutination ofPlasmodium falciparum–Infected Red Blood Cells and Disease Severity in Thailand
Open Access
- 15 March 2004
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 189 (6) , 1052-1055
- https://doi.org/10.1086/381900
Abstract
The relationship of the platelet-mediated autoagglutination of Plasmodium falciparum-infected red blood cells (IRBCs) to disease severity was investigated in 182 Thai patients with falciparum malaria; it was evident in 43% of uncomplicated malaria (n = 63), 41%of severemalaria (n = 104), and 100% of cerebral malaria (n = 15; P=.001) isolates. The median (range) number of IRBCs in agglutinates per 1000 IRBCs was significantly higher in cerebral malaria (6 [3-42]) than in severe (0 [0-52]) and uncomplicated (0 [0-24]) malaria (P=.01). In multivariate analyses, high parasitemia and cerebral malaria were associated independently with parasite agglutination.Keywords
This publication has 1 reference indexed in Scilit:
- Severe and complicated malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1990