Lipase-Catalyzed Highly Enantioselective Macrolactonization of Hydroxyacid Esters in an Organic Solvent

1 October 1989

journal article
research article
Published by Oxford University Press (OUP) in Chemistry Letters

Vol. 18 (10) , 1775-1776
https://doi.org/10.1246/cl.1989.1775

Abstract

In the lipase-catalyzed macrolactonization of long chain hydroxy acid methyl esters, the presence of a double bond in the acyl part was found to favor the formation of the monomeric product.

Keywords

ORGANIC SOLVENT
LIPASE CATALYZED
CATALYZED HIGHLY
HYDROXYACID ESTERS
ENANTIOSELECTIVE MACROLACTONIZATION
HIGHLY ENANTIOSELECTIVE

This publication has 3 references indexed in Scilit:

Macrocyclic lactones via biocatalysis in non-aqueous media
Tetrahedron Letters, 1988
Lipase catalyzed synthesis of macrocyclic lactones in organic solvents
Tetrahedron Letters, 1987
Optical rotatory dispersion and absolute configuration of some long-chain hydroxy acids
The Journal of Organic Chemistry, 1967