Effects of Membrane-Acting Drugs and Aerobiosis on Production of Streptolysin S and Nuclease in Hemolytic Streptococci

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Abstract
Yield of streptolysin S (SLS) in streptococcal culture was considerably reduced by procaine, dibucaine, atropine or chlorpromazine at concentrations which scarcely affected production of an extracellular nuclease as well as the bacterial growth. Cerulenin was also inhibitory to SLS formation, but its effect was more pronounced on the nuclease production. By aerobiosis, the amount of SLS produced into culture supernatant was increased significantly; yield of the nuclease was unaffected.