The Bactericidal Activity of Human Serum Against Escherichia Coli

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Abstract
Summary and Conclusions: The bactericidal activity of human sera against Escherichia coli was studied. An inverse relationship between the number of E. coli present and the bactericidal activity of serum was established. Significant differences in the bactericidal potency of serum from different individuals and in the resistances to the bactericidal activity of serum of different strains of E. coli were found. The bactericidal activity was found to be heat labile and not restored by addition of fresh guinea pig sera. Sera drawn from different age groups did not vary significantly in bactericidal activity. There were no gross differences between the bactericidal activities of sera drawn from limited numbers of patients with cirrhosis, diabetes, pyelonephritis and carcinoma, and control sera.

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