Chronic and acute administration of typical and atypical antidepressants on activity of brain noradrenaline systems in the rat thiopentone anaesthesia model
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 84 (3) , 304-309
- https://doi.org/10.1007/bf00555203
Abstract
A behavioural model sensitive to manipulation of brain noradrenaline systems and with characteristics of beta-receptor mediation has been developed using the duration of thiopentone anaesthesia in the rat. Acute and chronic administration of various antidepressant agents was examined. In the acute phase, (30 min prior to thiopentone) the noradrenaline uptake-inhibiting tricyclic drugs and viloxazine increased anaesthesia duration in a dose-dependent fashion. The atypical antidepressants trazodone, iprindole, and mianserin did this only weakly, while the dopaminergic and serotonergic uptake-inhibiting antidepressants (respectively bupropion, nomifensine, and zimelidine, fluoxetine) markedly shortened anaesthesia duration. Chronic administration (for 15 days) prolonged anaesthesia duration measured 2 or 5 days after the last drug injection for all tricyclic agents, for the atypical antidepressants mianserin, iprindole, fluoxetine, and zimelidine, and for viloxazine.This publication has 28 references indexed in Scilit:
- A common mechanism of action for antidepressant drugs?Trends in Pharmacological Sciences, 1983
- Brain noradrenaline and anaesthesia: Further characterization of the beta-receptorNeuropharmacology, 1983
- Daily bupropion injections for 3 weeks attenuate the ne-stimulation of adenylate cyclase and the number of β-adrenergic recognition sites in rat frontal cortexNeuropharmacology, 1983
- Role of Neuronal Signal Input in the Down‐Regulation of Central Noradrenergic Receptor Function by Antidepressant DrugsJournal of Neurochemistry, 1982
- Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain 3-methoxy-4-hydroxyphenylethylene-glycol sulphate content.Life Sciences, 1981
- Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: Subsensitivity without reduction in β-adrenergic receptor bindingNeuropharmacology, 1980
- Intact presynaptic terminals required for beta‐adrenergic receptor regulation by desipramineJournal of Neurochemistry, 1979
- The development of cortical β-adrenoceptor subsensitivity in the rat by chronic treatment with trazodone, doxepin and mianserineNeuropharmacology, 1978
- Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analoguesNeuropharmacology, 1977
- A comparison of the inhibitory activities of iprindole and imipramine on the uptake of 5-hydroxytryptamine and noradrenaline in brain slicesLife Sciences, 1971