TIAPRIDE AND CHLORDIAZEPOXIDE IN ACUTE ALCOHOL WITHDRAWAL - A CONTROLLED CLINICAL-TRIAL

  • 1 January 1984
    • journal article
    • research article
    • Vol. 4  (5) , 321-326
Abstract
The efficacy of chlordiazepoxide and tiapride in the management of acute alcohol withdrawal syndrome was compared in a randomized, parallel-group, double-blind trial. The mean daily dose for both preparations on the first 2 days was 4 capsules, i.e., 200 mg for chlordiazepoxide and 400 mg for tiapride. Thereafter the patients were treated according to the relief of symptoms obtained. The treatment periods lasted 3-5 days. Both drugs effectively alleviated alcohol withdrawal symptoms, especially anxiety, fear, hallucinations, insomnia, sweating, tremor, abdominal pain and vertigo. Seventy percent of the patients in the chlordiazepoxide and 42% in the tiapride group considered the drug effective. The difference was statistically significant in favor of chlordiazepoxide (P < 0.05). Tiapride is an alternative drug in the treatment of this condition, if benzodiazepines are to be avoided.

This publication has 1 reference indexed in Scilit: