Some Optically Active N-(4-tert-Amino-1-methyl-2-butynyl)-substituted Succinimides and 2-Pyrrolidones and their Absolute Configurations.
- 1 January 1976
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 30b (6) , 517-520
- https://doi.org/10.3891/acta.chem.scand.30b-0517
Abstract
The enantiomers of N-(1-methyl-4-pyrrolidino-2-butynyl)-2-pyrrolidone, N-(1-methyl-4-pyrrolidino-2-butynyl)succinimide and N-(1-methyl-4-perhydroazepino-2-butynyl)succinimide were prepared from the enantiomers of 1-methyl-2-propynylamine to study their stereoselectivity as oxotremorine antagonists on the guinea pig ileum. The absolute configurations of the optically active compounds were established in 2 independent ways by correlation to (S)-1-methylpropylamine and to (R)-alanine.Keywords
This publication has 1 reference indexed in Scilit:
- Acetylene Compounds of Potential Pharmacological Value. VIII. N-(4-Dialkylamino-2-butynyl)-Substituted Cyclic Imides1Journal of Medicinal Chemistry, 1966