Concentrations of ionic and total calcium in plasma of four models of hypertension

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Abstract
The levels of ionic Ca in whole blood obtained from female Sprague-Dawley (SDR), Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats tended to decrease between 5-13 wk of age. During this interval the plasma total Ca levels of each strain remained stable, indicating an increase in the binding or complexing of endogenous Ca with maturation. The ionic Ca levels of WKY were lower than those of SDR, while SHR levels were below those of the WKY and SDR strains. Neither the 1-kidney, 1-clip (1KHT) nor the 2-kidney, 1-clip (2KHT) renovascular models of hypertension showed evidence of an alteration in blood ionic or total Ca concentrations compared with sham-operated controls. The ionic Ca levels of blood from deoxycorticosterone-treated (DOCA/saline) hypertensive rats were significantly reduced from those of sham-operated controls, but were similar to values recorded for normotensive uninephrectomized controls. Each of the 4 models of hypertension studied and the normotensive uninephrectomized control group demonstrated some degree of reduction in the in vitro binding or complexing of exogenous Ca. Apparently, the spontaneous, renovascular and mineralocorticoid forms of hypertension examined were accompanied by some disturbance in extracellular Ca homeostasis. It is unlikely that the alterations observed are primary causal factors in the maintenance of high blood pressure.

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