Combined Methods for Assessment of Neurotoxicity
- 1 November 1980
- journal article
- research article
- Published by Wolters Kluwer Health in Investigative Radiology
- Vol. 15, S248-S253
- https://doi.org/10.1097/00004424-198011001-00053
Abstract
A battery of tests for toxicity assessment of new contrast media is reviewed. Cell toxicity in a protozoan culture (Blepharisma americanum); lethal dose determination in mice; EEG Spectral analysis following cisternography in rabbits; ED50 and LD50 determination by intra- and pericerebral injection in rats; intracisternal injection in chronically cannulated, nonanesthetized rats; and aversive conditioning by intracisternal injection in rats were found complementary. By these methods, novel nonionic media phenyl-sugar-ether DS-1-132 and DL-2-99 were found comparable to iopamidol, while all three compounds were superior to metrizamide.Keywords
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