Decrease in the Concentrations of Transforming Growth Factor-beta1 in the Sera of Patients with Kawasaki Disease
- 1 January 1997
- journal article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 26 (4) , 314-317
- https://doi.org/10.3109/03009749709105322
Abstract
Kawasaki disease (KD) is one of the most important forms of vasculitis, and is characterized by the initiation of a proinflammatory cytokine cascade. To further characterize the immunological profile of KD, we measured the serum levels of transforming growth factor-beta 1 (TGF-beta 1) as a regulatory cytokine. We determined the concentration of TGF-beta 1 in the sera of the patients with KD, anaphylactoid purpura (AP), and scarlet fever, using a sandwich enzyme linked immunosorbent assay. The serum levels of TGF-beta 1 were decreased in patients with KD, but not in patients with AP or scarlet fever during the acute stage. We found an inverse correlation between TGF-beta 1 and soluble tumor necrosis factor (TNF) receptor levels in KD patients during the acute and subacute stage. Decreased levels of TGF-beta 1, in particular to suppress TNF alpha (TNF-alpha) production, is an important part of the regulatory system of increased TNF-alpha production which cause vasculitis.Keywords
This publication has 31 references indexed in Scilit:
- The endothelial cell:active participant or innocent bystander in primary vasculitis?Clinical and Experimental Immunology, 2008
- Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shockPublished by Elsevier ,2005
- Inhibition of human acetylcholinesterase by cyclophosphamideToxicology, 1995
- Nitric Oxide Production Depends on Preceding Tetrahydrobiopterin Synthesis by Endothelial Cells: Selective Suppression of Induced Nitric Oxide Production by Sepiapterin Reductase InhibitorsBiochemical and Biophysical Research Communications, 1994
- Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.Journal of Clinical Investigation, 1992
- Wegener Granulomatosis: An Analysis of 158 PatientsAnnals of Internal Medicine, 1992
- Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?The Lancet, 1991
- The American College of Rheumatology 1990 criteria for the classification of wegener's granulomatosisArthritis & Rheumatism, 1990
- The American College of Rheumatology 1990 criteria for the classification of churg‐strauss syndrome (allergic granulomatosis and angiitis)Arthritis & Rheumatism, 1990
- Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.Journal of Clinical Investigation, 1987