STUDIES IN CUSHING'S SYNDROME. III. URINARY 17-KETOSTEROIDS IN PATIENTS WITH BILATERAL ADRENAL CORTICAL HYPERPLASIA*

Open Access
Publisher Website
Google Scholar
Abstract
In Cushing s syndrome with bilateral adrenal hyperplasia urine 17-ketosteroids were fractionated by column chromatography (Lakshmanan and Lieberman) and identified by infrared spectroscopy. The excretory pattern in 7 patients showed the following characteristics: an absolute and relative increase in 11-oxygenated 17-ketosteroids; an absolute increase in 11 beta-hydroxyandrosterone; an average ratio of etiocholanolone to androsterone 4 times that found in normal subjects; and the absence of dehydroepiandrosterone in 5 of the 7 patients. Prolonged (2 years) administration of adrenocorticotropic hormone to 2 individuals without adrenal cortical disease was associated with a high ratio of etiocholanolone to androsterone.