The β-adrenoceptor of pig coronary arteries: determination of β1 and β2 subtypes by radioligand binding
Open Access
- 1 June 1983
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 79 (2) , 409-414
- https://doi.org/10.1111/j.1476-5381.1983.tb11013.x
Abstract
1 β-Adrenoceptors of pig coronary arteries were investigated by the use of a new ligand, 125iodocyanopindolol (ICYP) in binding studies. 2 Inhibition of ICYP binding by betaxolol (a selective β1-antagonist), zinterol (a selective β2-agonist) and ICI 118551 (a selective β2-blocking drug) resulted in non-linear Scatchard plots, suggesting that both β-adrenoceptor subtypes are present in pig coronary arteries. 3 Computer analysis of the data gave a β1:β2-adrenoceptor ratio of approximately 65:35.This publication has 16 references indexed in Scilit:
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