Posaconazole Enhances the Activity of Amphotericin B against Hyphae of Zygomycetes In Vitro
- 1 July 2008
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (7) , 2636-2638
- https://doi.org/10.1128/aac.00492-08
Abstract
The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed.Keywords
This publication has 22 references indexed in Scilit:
- Synergistic Effect of Posaconazole and Caspofungin against Clinical ZygomycetesAntimicrobial Agents and Chemotherapy, 2007
- In Vitro Susceptibilities of 217 Clinical Isolates of Zygomycetes to Conventional and New Antifungal AgentsAntimicrobial Agents and Chemotherapy, 2007
- In Vitro Activities of Amphotericin B, Caspofungin, Itraconazole, Posaconazole, and Voriconazole against 45 Clinical Isolates of Zygomycetes: Comparison of CLSI M38-A, Sensititre YeastOne, and the EtestAntimicrobial Agents and Chemotherapy, 2007
- Posaconazole Enhances the Activity of Amphotericin B against Aspergillus Hyphae In VitroAntimicrobial Agents and Chemotherapy, 2007
- Posaconazole Prophylaxis in Experimental Systemic ZygomycosisAntimicrobial Agents and Chemotherapy, 2007
- Effects of Lipid Formulations of Amphotericin B on Activity of Human Monocytes against Aspergillus fumigatusAntimicrobial Agents and Chemotherapy, 2006
- Lovastatin Has Significant Activity against Zygomycetes and Interacts Synergistically with VoriconazoleAntimicrobial Agents and Chemotherapy, 2006
- PosaconazoleDrugs, 2005
- In vitro studies on the activity of amphotericin B and lipid‐based amphotericin B formulations against Aspergillus conidia and hyphaeMycoses, 2002
- Successful Treatment of Sinusitis Caused by Cunninghamella bertholletiaeClinical Infectious Diseases, 1994