Sphingosine 1-Phosphate Contracts Canine Basilar Arteries In Vitro and In Vivo
- 1 December 2001
- journal article
- Published by Wolters Kluwer Health in Stroke
- Vol. 32 (12) , 2913-2919
- https://doi.org/10.1161/hs1201.099525
Abstract
Background and Purpose— Sphingosine 1-phosphate (S1P) is a platelet-derived bioactive lipid that exerts a variety of biological responses, including vasocontraction. To understand the involvement of S1P in cerebral vasospasm, we investigated the effect of S1P on vasocontraction of the canine basilar artery in vitro and in vivo.Keywords
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