Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides
Open Access
- 1 September 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (9) , 3054-3056
- https://doi.org/10.1128/aac.46.9.3054-3056.2002
Abstract
Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.Keywords
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