The Spatio-Temporal Course of Wallerian Degeneration within the CNS of Toads (Bufo marinus) as Defined by the Nauta Silver Method
- 1 January 1972
- journal article
- Published by S. Karger AG in Brain, Behavior and Evolution
- Vol. 5 (1) , 1-17
- https://doi.org/10.1159/000123734
Abstract
The spatio-temporal development of Nauta-positive degeneration within various regions of toad (Bufo marinus) CNS has been microscopically assessed in animals maintained at 20 or 30 °C following unilateral section of the 9th spinal dorsal root. The results suggest that Wallerian degeneration proceeds in a somatofugal manner, that small-diameter fibers degenerate more rapidly than those of larger diameter, that short axon collaterals degenerate before longer ones, that CNS and PNS axons have equivalent degeneration rates, and that the rate of degeneration is constant along the axon proper but diminishes substantially in the preterminal-terminal region. The results further indicate that, over the temperature range employed, the Q10 of Wallerian degeneration for whole axons in Bufo marinus is 3.5, but is less than this for ''axons proper'' and greater than this for ''preterminal-terminal regions''.Keywords
This publication has 0 references indexed in Scilit: