Phenazopyridine induced methaemoglobinaemia associated with decreased activity of erythrocyte cytochrome b5 reductase.
Open Access
- 1 August 1983
- journal article
- case report
- Published by BMJ in Journal of Medical Genetics
- Vol. 20 (4) , 307-309
- https://doi.org/10.1136/jmg.20.4.307
Abstract
A 25-year-old woman taking usual doses of phenazopyridine developed her third clinically significant episode of cyanosis. Life threatening methaemoglobinaemia was documented and was treated with methylene blue. The patient and several members of her family showed decreased activities of erythrocyte NADH-cytochrome b5 reductase, predisposing them to the development of clinically significant methaemoglobinaemia when challenged with oxidant drugs.Keywords
This publication has 12 references indexed in Scilit:
- Methaemoglobinaemia.1981
- Methemoglobinemia from Sniffing Butyl NitriteAnnals of Internal Medicine, 1979
- Drug-induced methemoglobinemia.1973
- Catalysis of Methaemoglobin Reduction by Erythrocyte Cytochrome b5 and Cytochrome b5 ReductaseNature New Biology, 1971
- Methemoglobinemia Provoked by Malarial Chemoprophylaxis in VietnamNew England Journal of Medicine, 1968
- New method for determining ferrihemoglobin reductase (NADH-methemoglobin reductase) in erythrocytes.1968
- Syndrome of Bilateral Pheochromocytoma, Medullary Thyroid Carcinoma and Multiple NeuromasNew England Journal of Medicine, 1968
- Methemoglobinemia and Heinz Body Hemolytic Anemia Due to Phenazopyridine HydrochlorideNew England Journal of Medicine, 1964
- THE RELATION OF DIAPHORASE OF HUMAN ERYTHROCYTES TO INHERITANCE OF METHEMOGLOBINEMIAJournal of Clinical Investigation, 1960
- METHEMOGLOBINEMIA ASSOCIATED WITH PYRIDIUM® ADMINISTRATIONJAMA, 1951