Force and Voltage Sensors in One Structure
- 22 November 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 298 (5598) , 1562-1563
- https://doi.org/10.1126/science.1079369
Abstract
To respond to sudden changes in osmolality, most prokaryotes have mechanosensitive channels that open in response to tension and so prevent the cell-membrane from bursting. In their perspective, Bezanilla and Perozo discuss new work (Bass et al.) on the structure of a small-conductance mechanosensitive channel (MscS) that provides new insights into how the cell senses and responds to changes in tension and voltage.Keywords
This publication has 15 references indexed in Scilit:
- Crystal Structure of Escherichia coli MscS, a Voltage-Modulated and Mechanosensitive ChannelScience, 2002
- Open channel structure of MscL and the gating mechanism of mechanosensitive channelsNature, 2002
- The open pore conformation of potassium channelsNature, 2002
- [24] Mechanosensitive channels of bacteriaPublished by Elsevier ,1999
- The Structure of the Potassium Channel: Molecular Basis of K + Conduction and SelectivityScience, 1998
- MECHANOSENSITIVE CHANNELS OFESCHERICHIA COLI:The MscL Gene, Protein, and ActivitiesAnnual Review of Physiology, 1997
- Characterization of mechanosensitive channels in Escherichia coli cytoplasmic membrane by whole-cell patch clamp recordingThe Journal of Membrane Biology, 1995
- A large-conductance mechanosensitive channel in E. coli encoded by mscL aloneNature, 1994
- Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitutionBiophysical Journal, 1993
- Pressure-sensitive ion channel in Escherichia coli.Proceedings of the National Academy of Sciences, 1987