The significance of the non-fermentable reducing substances of the blood in diabetes

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Abstract
The amounts of non-fermentable reducing substances of blood range from 16 to 31 mgm. per 100 cc, expressed as glucose. No great differences were found between normal and diabetic, or between the blood of children and of adults, in this respect. In all cases the quantities were fairly constant for a given individual. Administration of large amounts of glucose did not cause any change in the concentration of the non-fermentable reducing substance, although typical "blood-sugar curves" were obtained in both normal and diabetic subjects. Similar tests gave similar results when both venous and arterial blood-samples were compared. Insulin also caused no change in this fraction when given to diabetics, who experienced the usual hypoglycemia and clinical reaction. The conclusion is drawn that the metabolism of the non-fermentable substances is not disturbed in diabetes.

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