Determination of Tylosin and Tilmicosin Residues in Animal Tissues by Reversed-Phase Liquid Chromatography
- 1 March 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of AOAC INTERNATIONAL
- Vol. 77 (2) , 331-333
- https://doi.org/10.1093/jaoac/77.2.331
Abstract
A method for the simultaneous determination of ty-losin and tilmicosin residues in animal tissues is reported. Solid-phase extraction columns are used to isolate the drugs from tissue extracts. Determination is accomplished by reversed-phase liquid chromatography with UV detection at 287 nm. Mean recoveries from spiked tissues were 79.9% (coefficient of variation [CV], 8.1%) for tylosin and 92.6% (CV, 8.7%) for tilmicosin. Detection limits for tylosin and tilmicosin were 0.020 and 0.010 ppm, respectively.Keywords
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