Site-Specific Amino Acid Frequency, Fitness and the Mutational Landscape Model of Adaptation in Human Immunodeficiency Virus Type 1
- 1 November 2006
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 174 (3) , 1689-1694
- https://doi.org/10.1534/genetics.106.062885
Abstract
Analysis of the intensely studied HIV-1 gp120 V3 protein region reveals that the among-population mean site-specific frequency of an amino acid is a measure of its relative marginal fitness. This surprising result may arise if populations are displaced from mutation–selection equilibrium by fluctuating selection and if the probability of fixation of a beneficial amino acid is proportional to its selection coefficient.Keywords
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