3′‐(1,2,3‐Triazol‐1‐yl)‐2′,3′‐dideoxythymidine and 3′‐(1,2,3‐triazol‐1‐yl)‐2′,3′‐dideoxyuridine
- 1 November 1989
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 26 (6) , 1635-1642
- https://doi.org/10.1002/jhet.5570260624
Abstract
Cycloaddition of different acetylenic compounds on the azido function of 3′‐azido‐2′,3′‐dideoxythymidine and 3′‐azido‐2′,3′‐dideoxyuridine afforded products with a 1,2,3‐triazol‐1‐yl substituent in the 3′‐position. In contrast with the parent compounds, these triazolyl derivatives had no appreciable activity against human immunodeficiency virus (HIV‐1).Keywords
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