Complement-Unlike Hemolytic Activity in Lobster Hemolymph
Open Access
- 1 October 1972
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 109 (4) , 816-823
- https://doi.org/10.4049/jimmunol.109.4.816
Abstract
Hemagglutinating and cobra venom factor (CVF)-activated hemolytic activities were found in the hemolymph of the lobster, Homarus americanus. The substances in hemolymph responsible for these two activities were separated and shown to be mutually independent. Hemolytic activity was due to the action of a low level of phospholipase A in the CVF preparation on lobster hemolymph lipoprotein. Lecithin was converted to lysolecithin. Phospholipase A activity was also demonstrated in a commercial preparation of CVF. Lecithin and human lipoproteins as well as lobster lipoproteins were suitable substrates for both CVF preparations.Keywords
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