Abstract
In their investigations on the effect of weight loss on serum androgens in obese women with and without polycystic ovary syndrome (PCOS), Jakubowicz and Nestler (1) measured the concentrations in plasma of testosterone, free testosterone, and sex hormone-binding globulin (SHBG). Among their observations was that, although testosterone and free testosterone fell significantly after weight loss in patients with PCOS, this was not true in the weight-matched patients without PCOS.