The Refractory State after Induction of Interferon with Double-stranded RNA

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Abstract
The picornaviruses have a wide range of buoyant densities in caesium chloride. Whereas the density of the pH 3-stable viruses is 1.34 g./ml. (Mattern, 1962; Schaffer & Frommhagen, 1965), the acid-sensitive rhinoviruses and foot-and-mouth disease viruses have densities of 1.38–1.41 g./ml. (Dans, Forsyth & Chanock, 1966; Chapple & Harris, 1966; McGregor, Phillips & Mayor, 1966; Gerin et al. 1968) and 1.43 g./ml. (Trautman & Breese, 1962; Wild & Brown, 1967). Although the reason for this difference in density is not understood, it seems likely that the higher values obtained with the acid-labile group are due to reaction of the caesium ions with the more accessible RNA of these viruses (McGregor et al., 1966). Recently, however, McGregor & Mayor (1968) suggested, on the basis of comparative measurements of the strand lengths of the ribonucleoproteins isolated from strains of poliovirus and rhinovirus, that the higher buoyant density of the rhinovirus was due to the high molecular weight (4 × 106) of the virus RNA.

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