Immunohistological features of synovitis in ankylosing spondylitis: a comparison with rheumatoid arthritis.
Open Access
- 1 February 1989
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 48 (2) , 92-98
- https://doi.org/10.1136/ard.48.2.92
Abstract
The immunohistological features of the synovial membrane in ankylosing spondylitis, HLA-B27 associated oligoarthritis, and rheumatoid arthritis wer examined with particular reference to T lymphocyte subsets. T helper (CD4+) cells clearly outnumbered T suppressor/cytotoxic (CD8+) cells in rheumatoid arthritis, whereas both cell types were present in equal numbers in ankylosing spondylitis. A reduction of CD4+/CD45R+ suppressor/inducer cells relative to CD4+/UCHL1+ helper/inducer cells was apparent in all diagnostic groups. The observations were suggestive of disease specific inflammatory responses within synovial membrane.This publication has 26 references indexed in Scilit:
- Use of the monoclonal antibody WR17, identifying the CD37 gp40–45 Kd antigen complex, in the diagnosis of B‐lymphoid malignancyThe Journal of Pathology, 1987
- An investigation of the action of disease modifying antirheumatic drugs on the rheumatoid synovial membrane: reduction in T lymphocyte subpopulations and HLA-DP and DQ antigen expression after gold or penicillamine therapy.Annals of the Rheumatic Diseases, 1987
- Aortic arch syndrome associated with anticadiolipin antibodies and the lupus anticoagulant: Comment on Ferrante paperArthritis & Rheumatism, 1985
- Phenotypic characterization of synovial tissue cells in situ in different types of synovitisArthritis & Rheumatism, 1983
- Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferationInternational Journal of Cancer, 1983
- Histopathology of the synovial membrane of peripheral joints in ankylosing spondylitis.Annals of the Rheumatic Diseases, 1982
- ASSOCIATIONS BETWEEN ANKYLOSING SPONDYLITIS, PSORIATIC ARTHRITIS, REITERʼS DISEASE, THE INTESTINAL ARTHROPATHIES, AND BEHCETʼS SYNDROMEMedicine, 1974
- Enthesopathy of rheumatoid and ankylosing spondylitis.Annals of the Rheumatic Diseases, 1971
- Clinical Features and Course of Ankylosing SpondylitisAnnals of the Rheumatic Diseases, 1958
- Histopathology of Diarthrodial Joints in Ankylosing SpondylitisAnnals of the Rheumatic Diseases, 1951