The Synthesis of N-Terminal Acetylpeptides of Ovalbumin and Mammalian Heart Cytochrome c

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Abstract
In previous studies acetylglycylserine and acetylglycylaspartylalylglutamic acid had been isolated from the enzymatic digests of ovalbumin and cytochromes c of bovine and equine hearts respectively. Here, in order to confirm the structures of the acetylpeptides isolated, acetylglycyl-L-serine and acetylglycyl-L-aspartyl-L-valyl-L-glutamic acid have been synthesized. It has been proved that the natural acetylpeptides are identical with the synthetic ones in every respect examined. Some troubles encountered during the synthesis of the acetyltetrapeptide have been discussed.