Multiple molecular forms of arylsulfatase A in different forms of metachromatic leukodystrophy (MLD)

1 January 1979

journal article
research article
Published by Wolters Kluwer Health in Neurology

Vol. 29 (1) , 16
https://doi.org/10.1212/wnl.29.1.16

Abstract

Arylsulfatase A (ARA) can be separated into six to eight individual enzymatic bands of activity by isoelectric focusing on cellulose acetate membranes. The residual ARA activity in juvenile metachromatic leukodystrophy (MLD) has a single band of activity with a pI of 5.5, whereas the residual ARA in the late infantile form of MLD has three bands of activity with a pI range of from 5.4 to 5.8. The technique of isoelectric focusing on cellulose acetate membranes demonstrates enzymatic differences which can be correlated with the clinical form of the disease.

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