Cyclization of nucleotide analogues as an obstacle to polymerization
- 1 December 1988
- journal article
- letter
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 28 (1-2) , 170-171
- https://doi.org/10.1007/bf02143509
Abstract
Cyclization of activated nucleotide analogues by intramolecular phosphodiester-bond formation is likely to compete very effectively with template-directed condensation except in the cases of ribo- and arabinonucleotides. This could have excluded derivatives of most sugars from growing polyribonucleotide chains and thus reduced chain-termination in prebiotic polynucleotide synthesis.Keywords
This publication has 6 references indexed in Scilit:
- Nucleic acid-like structures II. Polynucleotide analogues as possible primitive precursors of nucleic acidsDiscover Life, 1987
- The case for an ancestral genetic system involving simple analogues of the nucleotides.Proceedings of the National Academy of Sciences, 1987
- Synthesis, structure, and biological activity of certain 2-deoxy-.beta.-D-ribo-hexopyranosyl nucleosides and nucleotidesJournal of Medicinal Chemistry, 1987
- Evolution of the Genetic Apparatus: A ReviewCold Spring Harbor Symposia on Quantitative Biology, 1987
- Non-enzymatic template-directed synthesis on RNA random copolymersJournal of Molecular Biology, 1984
- Studies of oligoadenylate formation on a poly(U) templateJournal of Molecular Evolution, 1979