Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons
Open Access
- 1 September 2000
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Genome Research
- Vol. 10 (9) , 1304-1306
- https://doi.org/10.1101/gr.142200
Abstract
Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time. [The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990.]Keywords
This publication has 9 references indexed in Scilit:
- Human and Mouse Gene Structure: Comparative Analysis and Application to Exon PredictionGenome Research, 2000
- Human and mouse gene structurePublished by Association for Computing Machinery (ACM) ,2000
- Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence ComparisonsScience, 2000
- Analysis of vertebrate SCL loci identifies conserved enhancersNature Biotechnology, 2000
- Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.1998
- Long Human–Mouse Sequence Alignments Reveal Novel Regulatory Elements: A Reason to Sequence the Mouse GenomeGenome Research, 1997
- Large-Scale Comparative Sequence Analysis of the Human and Murine Bruton’s Tyrosine Kinase Loci Reveals Conserved Regulatory DomainsGenome Research, 1997
- Striking sequence similarity over almost 100 kilobases of human and mouse T–cell receptor DNANature Genetics, 1994
- A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer.The Journal of Immunology, 1992