Hygromycin B therapy of a murine coronaviral hepatitis
Open Access
- 1 October 1991
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 35 (10) , 2125-2127
- https://doi.org/10.1128/aac.35.10.2125
Abstract
Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied by direct infection and replication of virus within the liver. We demonstrate here that the aminoglycoside hygromycin B is able to eliminate MHV-A59 infection from mouse peritoneal macrophages and cultured liver cells in vitro and is also able to reduce levels of virus replication and necrotic liver foci in vivo.Keywords
This publication has 16 references indexed in Scilit:
- A Model for Persistent Murine Coronavirus Infection Involving Maintenance via Cytopathically Infected Cell CentresJournal of General Virology, 1989
- Translational Regulation in Mouse Hepatitis Virus Infection Is Not Mediated by Altered Intracellular Ion ConcentrationsJournal of General Virology, 1987
- Induction of Demyelination by a Temperature-sensitive Mutant of the Coronavirus MHV-A59 is Associated with Restriction of Viral Replication in the BrainJournal of General Virology, 1987
- Augmentation of organ-associated natural killer activity by biological response modifiers. Isolation and characterization of large granular lymphocytes from the liver.The Journal of Experimental Medicine, 1984
- Neutral-Red Uptake by Amniotic-Fluid Macrophages in Neural-Tube Defects: A Rapid TestNew England Journal of Medicine, 1984
- Intracellular accumulation of a fluorescent derivative of paromomycin in human fibroblastsJournal of Cellular Biochemistry, 1982
- Molecular biology of animal virus infectionPharmacology & Therapeutics, 1980
- The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblastsBiochemical Pharmacology, 1978
- In vivo and in vitro models of demyelinating diseases: Tropism of the JHM strain of murine hepatitis virus for cells of glial originCell, 1977
- Correlation of persistent mouse hepatitis virus (MHV-3) infection with its effect on mouse macrophage culturesArchiv für die gesamte Virusforschung, 1976