Action of 1,1,Dichloro-2- p -chlorophenyl-2- o -chlorophenylethane on Dog Adrenal Cortex
- 6 April 1962
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 136 (3510) , 47
- https://doi.org/10.1126/science.136.3510.47
Abstract
A single intravenous injection of op' DDD (1,1,dichloro-2- p -chlorophenyl-2- o -chlorophenylethane) has an acute effect on the adrenal cortex of the dog. Within 2 hours after intravenous injection of the drug, there is a decrease in the in vitro response of the adrenal cortex to stimulation by adrenocorticotrophic hormone and an inhibition of glucose-6-phosphate dehydrogenase activity. The inhibition of glucose-6-phosphate dehydrogenase activity might explain the effect of op' DDD on corticosteroid production.Keywords
This publication has 5 references indexed in Scilit:
- THE HISTOCHEMICAL DISTRIBUTION AND METABOLIC SIGNIFICANCE OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY, GLYCOGEN AND LIPID IN THE STIMULATED ADRENAL CORTEX1Endocrinology, 1961
- TPNH requirement for cholesterol side chain cleavage in adrenal cortexArchives of Biochemistry and Biophysics, 1959
- GLUCOSE-6-PHOSPHATE DEHYDROGENASE OF ADRENAL TISSUEJournal of Biological Chemistry, 1955
- [42] Glucose-6-phosphate dehydrogenase 6-phosphogluconic dehydrogenasePublished by Elsevier ,1955
- THE DETERMINATION OF 17, 21-DIHYDROXY-20-KETOSTEROIDS IN URINE AND PLASMAJournal of Biological Chemistry, 1954