In vitro Effect of YTR (Tazobactam) on Plasmid and Chromosomally Mediated β-Lactamases
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 36 (3) , 209-214
- https://doi.org/10.1159/000238768
Abstract
The effect of tazobactam on the piperacillin susceptibility and on the β-lactamase activity of different strains and species was evaluated. A synergistic effect was observed on the piperacillin susceptibility for all microorganisms tested, irrespective of the type and/or amount of β-lactamase produced. Addition of gentamicin resulted in a further reduction of the piperacillin MIC. The enzyme activity after induction with piperacillin alone or in combination with tazobactam (4 mg/l) was quite similar.Keywords
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