Hypogammaglobulinämie bei der Colisepsis des Kalbes

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Abstract
An introductory description of the Escherichia coli septicemia of calves and their immune status at birth is given. It is characterized by the fact that the calf is born without gamma globulins, which are passively acquired with the colostrum. Examinations of heart blood of calves, which had died of E. coli septicemia and had all received colostrum, showed that 21 of 22 of the animals were hypo- or even agammaglobulinemic. In comparison it was found that 5 of 46 normal calves of the same age (1 week of life) had a more or less pronounced hypogammaglobulinemia in spite of intake of colostrum. It is assumed that these facts are of probable pathogenetic importance and that such hypogammaglobuline-mic calves being exposed to a pathogenic E. coli type (78 80 B) shortly after birth develop an E. coli septicemia. Experimental infection of newborn calves with the E. coli type 78 :80 B was never possible if colostrum was given within reasonable time after birth and if, as far as tested, they became normogammaglobulinemic.

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