Ovarian Hyperstimulation Syndrome Due to a Mutation in the Follicle-Stimulating Hormone Receptor
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- 21 August 2003
- journal article
- case report
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 349 (8) , 760-766
- https://doi.org/10.1056/nejmoa030064
Abstract
The ovarian hyperstimulation syndrome most often occurs as an iatrogenic complication of ovarian-stimulation treatments for in vitro fertilization (the incidence of severe forms ranges from 0.5 to 5 percent).1 The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration in a third space.2 Although the presence of human chorionic gonadotropin is invariably associated with the condition, the pathophysiological mechanism remains undefined.3Keywords
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