mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation
- 16 November 2009
- journal article
- Published by Wiley in FEBS Letters
- Vol. 584 (1) , 124-128
- https://doi.org/10.1016/j.febslet.2009.11.041
Abstract
Resistance to anti‐estrogen therapy is a major clinical concern in treatment of breast cancer. Estrogen‐independent phosphorylation of estrogen receptor α, specifically on Ser167, is one of the contributing causes to development of resistance, and a prognostic marker for the disease. Here, we dissect the signaling pathways responsible for Ser167 phosphorylation. We report that the mTOR/S6K1 and MAPK/RSK contribute non‐overlapping inputs into ERα activation via Ser167 phosphorylation. This cooperation may be targeted in breast cancer treatment by a combination of mTOR and MAPK inhibitors.Keywords
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