Influence of the HLA-DRB1 locus on susceptibility and severity in rheumatoid arthritis
Open Access
- 1 November 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in QJM: An International Journal of Medicine
- Vol. 89 (11) , 821-830
- https://doi.org/10.1093/qjmed/89.11.821
Abstract
We examined HLA-DR genotype risks in 288 patients with rheumatoid arthritis who were carefully categorized for disease severity. Five hundred ethnically-matched bone-marrow donors were controls. A hierarchy of positive allelic associations was noted with DRB1*0401 (p<10−38), *0404,8 (p−43), *0405 (p−8), *10 (p−3) and *0101,2 (p−2), while DRB1*0403 was negatively associated (p = 0.02). The DRB1 genotype relative risks (and 95% CIs) for RA were: *0404/5,8/*O4O4,5,8 = 36.2 (15–87), *0401/*0404,5,8 = 31.3 (18–55), *0401/*0401 = 18.8 (11–35), *0101,2/*0404,5,8 = 6.0 (2–14), *0101,2/*0401 = 6.4 (3–12), *0101,2/*0101,2 = 1.3 (0.3–6), *10/*0404,5,8 = 27.8 (5–148), *10/*0401 = 20.8 (5–89), *10/*0101,2 = 22.3 (5–96), *0404,5,8/DRX = 5.0 (3–8), *0401/DRX = 4.7 (3–7), *0101,2/DRX = 2.3 (1.4–4), *10/DRX =3.4 (0.8–14). No significant correlation of DRB1 genotypes was found with severity of RA as judged by nodules or articular erosions.Keywords
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