Free radical reactions in synthesis. Homolysis of alkylcobalt complexes in the presence of radical-trapping agents
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 2703-2708
- https://doi.org/10.1039/p19900002703
Abstract
Irradiations of the alkylcobalt salophen complexes (14), (21), (22), and (23) in the presence of radical-trapping agents, e.g. molecular oxygen, tetramethylpiperidine oxide, nitrogen monoxide, diphenyl disulphide, diphenyl diselenide, methanesulphonyl chloride, bromotrichloromethane, or iodine, leads to oxgen-[e.g., (18), (19), and (25)], nitrogen-[e.g., (27) and (28)], sulphur/selenium-[e.g., (30) and (31)] or halogen-(34) functionalised products. When these radical-trapping methodologies are combined with cobalt-mediated radical cyclisation reactions (Scheme 2) a powerful synthetic procedure, i.e. radical carbon-to-carbon bond formation with simultaneous functionalisation of the product radical centre, becomes available.Keywords
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