Investigation of restricted backbone conformations as an explanation for the exceptional thermal stabilities of duplexes involving LNA (Locked Nucleic Acid):† synthesis and evaluation of abasic LNA
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 7,p. 657-658
- https://doi.org/10.1039/a900458k
Abstract
In order to investigate the structural basis of the unique hybridization properties of LNA (Locked Nucleic Acid), an abasic LNA monomer (a 1-deoxy-2-O,4-C-methylene-D-ribofuranose derivative) was synthesized and evaluated with respect to influence on duplex stability, showing that effects mediated via the nucleobase are pivotal for the properties of LNA.Keywords
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