Action of Penicillin on Staphylococcus. Effect of Size of Inoculum on the Test for Sensitivity.
- 1 November 1946
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 63 (2) , 443-446
- https://doi.org/10.3181/00379727-63-15629
Abstract
163 strains of Staphylococcus were tested for resistance to penicillin, using a broth dilution method. Replicate detns. were made using inocula containing either a few or many cells. It was shown that the action of penicillin against most strains of Staphylococcus is related only in a minor degree to the number of bacteria present. In a not inconsiderable group of strains, somewhat more resistant to penicillin than the majority, the outcome of tests for penicillin sensitivity is profoundly influenced by the number of cells present.Keywords
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