Retracted: Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals
- 23 May 2005
- journal article
- retracted article
- Published by Wiley in FEBS Letters
- Vol. 579 (14) , 3152-3158
- https://doi.org/10.1016/j.febslet.2005.04.075
Abstract
In this study, we demonstrate that pretreatment with aspirin inhibits GH-induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRSIPI(3)kinase pathway and a reduction in IRS-1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. Overall, these results provide new insights into the mechanism of GH-induced insulin resistance. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.Keywords
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