Erythropoietin as an antiapoptotic, tissue-protective cytokine
Top Cited Papers
- 9 July 2004
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 11 (S1) , S37-S44
- https://doi.org/10.1038/sj.cdd.4401450
Abstract
Erythropoietin (EPO) increases the number of circulating erythrocytes primarily by preventing apoptosis of erythroid progenitors. In addition to this proerythroid action, results of recent studies show that systemically administered EPO is protective in vivo, in several animal models of neuronal injury. In vitro, EPO prevents neuronal apoptosis induced by a variety of stimuli. This review summarizes the neuroprotective actions of EPO and discusses the underlying mechanisms in terms of signal transduction pathways involved. The understanding of these mechanisms will help differentiate the neuroprotective actions of EPO from its role in the bone marrow.Keywords
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