Mutation as a Cause of Death in Offspring of Irradiated Rats

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Abstract
The incidence of infant death (stillbirth and death up to weaning) was studied in litters sired by X-irradiated male rats. Litters were conceived throughout a 24-day period after irradiation. A quantitative assessment of the relative importance of direct and indirect genetic components was made. The major cause of increased infant death in combined litters from conceptions at all times following irradiation was found to be indirectly genetic, i.e., a result of reduced litter size. However, a significant increase in death among litters conceived at 5 to 8 days after irradiation could be attributed to direct genetic causes.

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