The effect of prefrontal lobotomy in rhesus monkeys on delayed-response performance motivated by painshock.

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Abstract
Monkeys trained in delayed alternation and discrimination with food-reward motivation and in a delayed response with shock-escape motivation either before or after prefrontal lobotomy showed the following effects of the operation: "prefrontal lobotomy in monkeys results in impairment in delayed response performance whether motivated by escape from pain or food. The anatomical results suggest that the caudate nucleus may have been involved in these changes.".