Cytochalasin B-induced triploidy in mouse oocytes fertilized in vitro

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Abstract
Mouse eggs and spermatozoa were treated in various ways with 5 or 10 .mu.g cytochalasin B/ml. The fertilization rate in vitro was reduced by treatment with the drug but 80-90% of the eggs fertilized were triploid. Many of the experimental eggs were penetrated by one or more spermatozoa but remained unfertilized (75% compared with 9% in control eggs). Cytochalasin B weakens the zona reaction and interferes with fusion of gametes but does not prevent the block to polyspermy.

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