INTESTINAL METAPLASIA AS A COMMON OPTION OF OVAL CELLS IN RELATION TO CHOLANGIOFIBROSIS IN LIVER OF RATS EXPOSED TO 2-ACETYLAMINOFLUORENE
- 1 January 1985
- journal article
- research article
- Vol. 52 (4) , 354-362
Abstract
Oval cell proliferation in the liver was studied in rats exposed to dietary 2-acetylaminofluorene for 2 wk with partial hepatectomy performed midway at 1 wk. Using autoradiography after either continuous or pulse exposure to [3H]thymidine, histochemical staining for leucine aminopeptidase and .gamma.-glutamyltransferase, and transmission electron microscopy, it was found that every animal showed islands of oval cells with small intestinal metaplasia at 3 wk. Transitions from these islands of metaplasia to cholangiofibrosis were commonly seen. The importance of small intestinal metaplasia of oval cells in the genesis of cholangiofibrosis is presented and discussed.This publication has 39 references indexed in Scilit:
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