Carbamazepine-induced syndrome of inappropriate antidiuretic hormone secretion. Reversal by concomitant phenytoin therapy

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Abstract
Inappropriate antidiuretic hormone secretion, with marked hyponatremia, was observed in an elderly woman who was taking carbamazepine for trigeminal neuralgia. Subsequent studies revealed this effect to be directly related to administration of the drug. Substantial H2O retention was not previously described in patients taking normal volumes of fluid and taking standard doses of carbamazepine. The antidiuretic effect of carbamazepine was blocked by phenytoin. Actions of both drugs on renal H2O excretion and interactions of the drugs apparently were dose-related.

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