Pharmacokinetics of cyclophosphamide in Kenyan Africans.
Open Access
- 26 July 1983
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 16 (1) , 61-63
- https://doi.org/10.1111/j.1365-2125.1983.tb02144.x
Abstract
The pharmacokinetics of cyclophosphamide was studied in 10 Kenyan Africans with Hodgkins lymphoma. The mean +/‐ s.d. elimination half‐ life (t1/2) was 7.5 +/‐ 1.38 h. The mean +/‐ s.d. volume of the central compartment (V1) was 0.35 +/‐ 0.12 l/kg and the apparent volume of distribution (V) was 0.64 +/‐ 0.06 l/kg. The microconstants k21, k12 and k10 were 1.81 +/‐ 0.84 h‐1, 1.90 +/‐ 1.080 h‐1 and 2.05 +/‐ 0.86 h‐ 1 respectively (mean +/‐ s.d.).This publication has 10 references indexed in Scilit:
- The pharmacokinetics of cyclophosphamide, phosphoramide mustard and nor‐ nitrogen mustard studied by gas chromatography in patients receiving cyclophosphamide therapy.British Journal of Clinical Pharmacology, 1980
- Some aspects of the gas—liquid chromatographic analysis of cyclophosphamide in plasmaJournal of Chromatography B: Biomedical Sciences and Applications, 1980
- Pharmacokinetics of cyclophosphamide and alkylating activity in man after intravenous and oral administration.British Journal of Clinical Pharmacology, 1979
- COMPARATIVE METABOLISM OF 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE-2-OXIDE (CYCLOPHOSPHAMIDE) AND ITS ENANTIOMERS IN HUMANS1979
- QUANTITATION BY GAS CHROMATOGRAPHY CHEMICAL IONIZATION MASS-SPECTROMETRY OF CYCLOPHOSPHAMIDE, PHOSPHORAMIDE MUSTARD, AND NORNITROGEN MUSTARD IN PLASMA AND URINE OF PATIENTS RECEIVING CYCLOPHOSPHAMIDE THERAPY1978
- Pharmacokinetics of intravenous cyclophosphamide in man, estimated by gas-liquid chromatographyCancer Chemotherapy and Pharmacology, 1978
- Genetic and environmental factors affecting drug disposition in manClinical Pharmacology & Therapeutics, 1977
- The Biotransformation of Cyclophosphamide in Man: Analysis of the Variation in Normal SubjectsActa Pharmacologica et Toxicologica, 1974
- Clinical pharmacology of cyclophosphamide.1973
- Pharmacokinetics of cyclophosphamide in manBritish Journal of Pharmacology, 1971